Spinal or epidural anesthesia associated with increased survival compared to general anesthesia for leg artery bypass surgery

Posted on Wednesday, November 25, 2020

Dr. Roberts and Dr. McIsaac

Dr. Derek Roberts (left) and Dr. Daniel McIsaac

A new study published in The BMJ shows that people who had surgery to improve blood flow in their legs under spinal or epidural anesthesia were less likely to die than those who were given general anesthesia.

General anesthesia involves using drugs to make a patient unconscious and inserting a tube into their windpipe to help with breathing. Spinal and epidural anesthesia directly freezes the nerves to the legs and can be combined with lighter forms of sedation which do not involve a breathing tube.

This study, the largest of its kind, looked at medical records of 20,988 people who had leg artery bypass surgery in Ontario, Canada, between 2002 and 2015. Approximately two thirds of these surgeries used general anesthesia and a third used spinal or epidural anesthesia.

The researchers found that 646 of the patients who had general anesthesia (4.4 percent) died within 30 days of their surgery compared to 204 of the patients who had spinal or epidural anesthesia (3.2 per cent). The results remained the same after the researchers adjusted for differences between the groups, such as how sick the patients were before surgery.

“We estimate that this finding could save at least 100 of the patients’ lives who undergo leg artery bypass surgeries every year both in Canada and the United States,” said lead author Dr. Derek Roberts, a vascular and endovascular surgeon at The Ottawa Hospital and incoming assistant professor at the University of Ottawa. “We hope to conduct a randomized controlled trial to confirm these results, but, in the meantime our findings suggest that we should increasingly perform more of these types of surgeries using spinal or epidural anesthesia techniques.”  

“We were surprised to find that some hospitals did these types of surgeries under spinal or epidural anesthesia more than 90 per cent of the time, while in others it was less than one per cent,” said senior author Dr. Daniel McIsaac, associate scientist and anesthesiologist at The Ottawa Hospital, associate professor at the University of Ottawa, and adjunct scientist at ICES. “We hope this study will help patients and physicians make more informed decisions about what type of anesthetic is best for each patient.”

The study also found that patients who had spinal or epidural anesthesia were able to leave the hospital half a day earlier than those who had general anesthesia.

The researchers estimate that if all leg artery bypass surgeries were done with spinal or epidural anesthesia, it could save $50 million in health care costs each year in Canada. In Ontario, the vast majority of these surgeries are done in specialty centres that can easily perform spinal or epidural anesthesia.

Close to 20,000 people have leg artery bypass surgery in Canada and the United States every year.

 

Reference: Association between neuraxial anaesthesia or general anaesthesia for lower limb revascularisation surgery in adults and clinical outcomes: population based comparative effectiveness study. Derek J Roberts, Sudhir K Nagpal, Dalibor Kubelik, Timothy Brandys, Henry T Stelfox, Manoj M Lalu, Alan J Forster, Colin JL McCartney, Daniel I McIsaac. The BMJ. November 25, 2020. https://www.bmj.com/content/371/bmj.m4104

Funders: This study was possible because of support from The Ottawa Hospital Foundation, The Ottawa Hospital Department of Surgery, The Ottawa Hospital Department of Anesthesiology & Pain Medicine, the Canadian Anesthesiologists’ Society, the University of Ottawa and ICES (which is supported by the Ontario Ministry of Health).

About the University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca

About The Ottawa Hospital 
The Ottawa Hospital is one of Canada’s top learning and research hospitals, where excellent care is inspired by research and driven by compassion. As the third-largest employer in Ottawa, our support staff, researchers, nurses, physicians, and volunteers never stop seeking solutions to the most complex health-care challenges. Our multi-campus hospital, affiliated with the University of Ottawa, attracts some of the most influential scientific minds from around the world. Backed by generous support from the community, we are committed to providing the world-class, compassionate care we would want for our loved ones. www.ohri.ca

About ICES
ICES is an independent, non-profit research institute that uses population-based health information to produce knowledge on a broad range of health care issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting health care needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad, and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. In October 2018, the institute formerly known as the Institute for Clinical Evaluative Sciences formally adopted the initialism ICES as its official name. For the latest ICES news, follow us on Twitter: @ICESOntario
 
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